| 2026 | Ice Age 6 | Sid (voice) | ★ 0.0 |
| 2026 | The Odyssey | | ★ 0.0 |
| 2025 | Tin Soldier | Luke | ★ 0.0 |
| 2025 | Bob Trevino Likes It | Bob Trevino | ★ 7.1 |
| 2022 | Violent Night | Scrooge | ★ 7.3 |
| 2022 | The Menu | Movie Star | ★ 7.2 |
| 2022 | John Leguizamo Live at Rikers | | ★ 0.0 |
| 2022 | The Survivor | Bill "Pepe" Miller | ★ 6.9 |
| 2021 | Encanto | Bruno Madrigal (voice) | ★ 7.6 |
| 2021 | Dark Blood | Misael | ★ 5.1 |
| 2021 | Waiting for Godot | Estragon | ★ 5.0 |
| 2020 | Critical Thinking | Mario Martinez | ★ 6.5 |
| 2020 | The Night Clerk | Detective Espada | ★ 6.2 |
| 2019 | Chaos auf der Feuerwache | Rodrigo | ★ 6.6 |
| 2019 | Raúl Juliá: The World’s a Stage | Self | ★ 0.0 |
| 2019 | The Sun Is Also a Star | Jeremy Martinez | ★ 7.0 |
| 2019 | It Takes a Lunatic | Self | ★ 5.3 |
| 2018 | John Leguizamo's Latin History for Morons | Self | ★ 7.5 |
| 2018 | Nancy | Jeb | ★ 5.8 |
| 2017 | 11:55 | Berto | ★ 4.5 |
| 2017 | John Wick: Kapitel 2 | Aurelio | ★ 7.3 |
| 2017 | Die Wall Street Verschwörung | George Diebold | ★ 4.6 |
| 2016 | The Hollow Point | Atticus | ★ 5.8 |
| 2016 | Scrat: Verpeilt im Weltall | Sid (voice, uncredited) | ★ 6.3 |
| 2016 | Perros | Misael | ★ 5.0 |
| 2016 | The Infiltrator | Emir Abreu | ★ 6.7 |
| 2016 | Ice Age - Kollision voraus! | Sid (voice) | ★ 6.1 |
| 2016 | Porzingod | | ★ 8.0 |
| 2016 | Stealing Cars | Montgomery De La Cruz | ★ 6.3 |
| 2016 | Ice Age - Jäger der verlorenen Eier | Sid (voice) | ★ 6.4 |
| 2016 | Michael Jackson's Journey from Motown to Off the Wall | Self | ★ 7.0 |
| 2015 | Sisters | Dave | ★ 6.0 |
| 2015 | The Latin Explosion: A New America | Self - Narrator | ★ 7.9 |
| 2015 | Scrat-tastrophe im All | Sid (voice) | ★ 6.5 |
| 2015 | Experimenter | Taylor | ★ 6.5 |
| 2015 | Meadowland | Pete | ★ 5.8 |
| 2015 | American Ultra | Rose | ★ 6.1 |
| 2015 | Voll auf die Nuss | Fly Boy / Liam (voice) | ★ 5.2 |
| 2015 | John Wick: Calling in the Cavalry | Self | ★ 7.2 |
| 2014 | Fugly! | Jesse | ★ 4.5 |
| 2014 | Super Mario Bros: This Ain't No Video Game | Self - Luigi Mario | ★ 4.4 |
| 2014 | John Wick | Aurelio | ★ 7.4 |
| 2014 | Anarchie | Pisanio | ★ 3.9 |
| 2014 | Kiss the Cook | Martin | ★ 7.1 |
| 2014 | John Leguizamo: Ghetto Klown | Himself | ★ 6.6 |
| 2014 | Ride Along | Santiago | ★ 6.3 |
| 2013 | Dinosaurier 3D - Im Reich der Giganten | Alex (voice) | ★ 6.2 |
| 2013 | The Counselor | Coverall Man Randy | ★ 5.3 |
| 2013 | Kick-Ass 2 | Javier | ★ 6.4 |
| 2013 | Tales From a Ghetto Klown | Self | ★ 0.0 |
| 2013 | Fish N Chips: The Movie | Chips (voice) | ★ 2.3 |
| 2012 | El paseo 2 | Lucho | ★ 6.8 |
| 2012 | Ice Age 4 - Voll verschoben | Sid (voice) | ★ 6.4 |
| 2012 | Einmal ist keinmal | Jimmy Alpha | ★ 5.6 |
| 2011 | Ice Age - Eine coole Bescherung | Sid (voice) | ★ 6.5 |
| 2011 | Voll abgedriftet, Teil 2 | Sid (voice) | ★ 6.5 |
| 2011 | Pelotero | Narrator (voice) | ★ 6.2 |
| 2011 | The Latino List | Self | ★ 7.0 |
| 2011 | Der Mandant | Val Valenzuela | ★ 7.2 |
| 2010 | Die Herrschaft der Schatten | Paul | ★ 5.3 |
| 2010 | Repo Men | Asbury | ★ 6.3 |
| 2009 | Unearthing the Lost World | Ice Age: Dawn of the Dinosaurs | Self | ★ 0.0 |
| 2009 | The Ministers - Mein ist die Rache | Dante Mendoza | ★ 4.5 |
| 2009 | Rage | Jed | ★ 3.5 |
| 2009 | Gamer | Freek | ★ 5.7 |
| 2009 | Ice Age 3 - Die Dinosaurier sind los | Sid (voice) | ★ 6.8 |
| 2008 | Nothing Like the Holidays | Mauricio Rodriguez | ★ 6.4 |
| 2008 | Sids Sommer-Camp - Rette sich, wer kann | Sid (voice) | ★ 6.2 |
| 2008 | Visions of 'The Happening' | Himself | ★ 0.0 |
| 2008 | The Happening: Elements of a Scene | Self | ★ 0.0 |
| 2008 | Buffalo Soldiers ´44 - Das Wunder von St. Anna | Enrico | ★ 6.1 |
| 2008 | Kurzer Prozess - Righteous Kill | Detective Simon Perez | ★ 5.9 |
| 2008 | The Happening | Julian | ★ 5.4 |
| 2008 | The Babysitters - Für Taschengeld mache ich alles | Michael Beltran | ★ 6.0 |
| 2008 | Paraiso Travel | Roger Pena | ★ 6.9 |
| 2007 | Die Liebe in den Zeiten der Cholera | Lorenzo Daza | ★ 6.6 |
| 2007 | Der Weihnachtswunsch | Frank Diaz | ★ 6.9 |
| 2007 | ShowBusiness: The Road to Broadway | Self | ★ 7.2 |
| 2007 | The Take - Rache ist das Einzige, was zählt | Felix De La Pena | ★ 5.5 |
| 2006 | Die Freunde des Bräutigams | TC (Tony) | ★ 5.3 |
| 2006 | Ice Age 2 – Jetzt taut’s | Sid (voice) | ★ 6.7 |
| 2006 | Alibi | Hannibal | ★ 5.7 |
| 2005 | Sueño | Antonio | ★ 4.6 |
| 2005 | Land of the Dead | Cholo | ★ 6.2 |
| 2005 | Honeymooners | Dodge | ★ 4.1 |
| 2005 | Das Ende - Assault on Precinct 13 | Beck | ★ 6.2 |
| 2004 | Cronicas - Das Monster von Babahoyo | Manolo Bonilla | ★ 6.4 |
| 2003 | Undefeated - Der Sieger | Lex Vargas | ★ 3.0 |
| 2003 | Spun - Leben im Rausch | Spider Mike | ★ 6.6 |
| 2002 | Imperium - Zwei Welten prallen aufeinander | Victor Rosa | ★ 6.0 |
| 2002 | Der Brandstifter | Keith Lang | ★ 6.4 |
| 2002 | Zig Zag | Dean Singer | ★ 5.8 |
| 2002 | AFI's 100 Years... 100 Passions: America's Greatest Love Stories | Self | ★ 7.0 |
| 2002 | John Leguizamo: Sexaholix... A Love Story | himself | ★ 5.5 |
| 2002 | Ice Age | Sid (voice) | ★ 7.4 |
| 2002 | Collateral Damage - Zeit der Vergeltung | Felix Ramirez | ★ 5.8 |
| 2001 | De Superman à Spider-Man: L'aventure des super-héros | Clown / Violator (archive footage) | ★ 6.9 |
| 2001 | Dr. Dolittle 2 | Rat #2 (voice, uncredited) | ★ 5.3 |
| 2001 | Schlimmer geht's immer! | Berger | ★ 5.4 |
| 2001 | Moulin Rouge | Toulouse-Lautrec | ★ 7.5 |
| 2001 | The Night Club of Your Dreams: The Making of 'Moulin Rouge' | Self | ★ 6.5 |
| 2000 | King of the Jungle | Seymour | ★ 5.2 |
| 2000 | Titan A.E. | Gune (voice) | ★ 6.6 |
| 1999 | Summer of Sam | Vinny | ★ 6.5 |
| 1999 | Joe the King | Jorge | ★ 6.1 |
| 1998 | Kids Are Punny | | ★ 5.0 |
| 1998 | John Leguizamo: Freak | Self | ★ 6.0 |
| 1998 | Frogs for Snakes | Zip | ★ 2.0 |
| 1998 | Dr. Dolittle | Rat #2 (Voice) | ★ 5.7 |
| 1998 | Body Count - Flucht nach Miami | Chino | ★ 5.4 |
| 1997 | Spawn | Clown / Violator | ★ 5.4 |
| 1997 | The Making of 'Spawn' | Self | ★ 7.7 |
| 1997 | A Brother's Kiss | Lefty | ★ 7.8 |
| 1997 | Spawn The Director's Cut | Clown / Violator | ★ 10.0 |
| 1997 | The Pest - Jagd auf das Chamäleon | Pest | ★ 4.6 |
| 1996 | William Shakespeares Romeo + Julia | Tybalt | ★ 6.8 |
| 1996 | The Fan | Manny | ★ 6.0 |
| 1996 | Einsame Entscheidung | Rat | ★ 6.3 |
| 1995 | To Wong Foo, Thanks for Everything! Julie Newmar | Chi-Chi Rodriguez | ★ 7.4 |
| 1995 | Brennende Liebe | Sergio | ★ 4.9 |
| 1993 | Carlito's Way | Benny Blanco | ★ 7.8 |
| 1993 | Night Owl | Angel | ★ 4.2 |
| 1993 | Super Mario Bros. | Luigi Mario | ★ 4.4 |
| 1993 | John Leguizamo: Spic-O-Rama | | ★ 6.5 |
| 1992 | Stimmen im Dunkel | John Castillo | ★ 5.0 |
| 1992 | The Puerto Rican Mambo (Not a Musical) | Guess my nationality guy | ★ 0.0 |
| 1992 | Time Expired | | ★ 1.0 |
| 1991 | Mambo Mouth | | ★ 8.0 |
| 1991 | That Burning Question | | ★ 0.0 |
| 1991 | In Sachen Henry | Liquor Store Gunman | ★ 6.5 |
| 1991 | Deadly Revenge - Das Brooklyn Massaker | Boy in Alley | ★ 6.1 |
| 1991 | Hangin' with the Homeboys | Johnny | ★ 6.0 |
| 1991 | Poison | Chancho ("Homo") | ★ 6.1 |
| 1991 | NYPD Mounted | | ★ 0.0 |
| 1990 | Madonna: The Immaculate Collection | Friend of Boyfriend (segment "Borderline") | ★ 8.6 |
| 1990 | Street Hunter | Angel | ★ 6.3 |
| 1990 | Stirb langsam 2 | Burke | ★ 7.0 |
| 1990 | Revenge - Eine gefährliche Affäre | Ignacio | ★ 6.5 |
| 1989 | Die Verdammten des Krieges | Private Antonio Diaz | ★ 7.2 |
| 1984 | Mixed Blood - Die Ratten von Harlem | Macetero | ★ 5.9 |
| The Godmother | | ★ 0.0 |
| Gentille Alouette | Ortiz | ★ 10.0 |
| Encanto 2 | Bruno Madrigal (voice) | ★ 0.0 |
