| 2025 | George Lopez: Streng katholisch | Self | ★ 0.0 |
| 2024 | The Underdoggs | Coach Feis | ★ 7.1 |
| 2023 | Gone Before His Time: Freddie Prinze Sr. | Self (archive footage) | ★ 0.0 |
| 2023 | How the Gringo Stole Christmas | Bennie | ★ 6.0 |
| 2023 | Blue Beetle | Rudy Reyes | ★ 6.7 |
| 2023 | Fool's Paradise | George Lopez | ★ 4.6 |
| 2022 | DreamWorks The Boss Baby: Weihnachtsbonus | Santa (voice) | ★ 6.7 |
| 2022 | North of the 10 | The Man | ★ 4.5 |
| 2021 | Christmas in Tahoe | Otis | ★ 6.1 |
| 2021 | Walking with Herb | Herb | ★ 6.7 |
| 2021 | No Man's Land | Ramirez | ★ 6.3 |
| 2020 | Best of Stand-up 2020 | Self | ★ 6.0 |
| 2020 | At Last | Diego | ★ 4.0 |
| 2020 | In Search of the Sanderson Sisters: A Hocus Pocus Hulaween Takeover | Bargain Book | ★ 7.1 |
| 2020 | Cats & Dogs 3 - Pfoten vereint! | Pablo the Parrot (voice) | ★ 6.1 |
| 2020 | The Tax Collector | Uncle Louis | ★ 5.6 |
| 2020 | George Lopez: We'll Do It for Half | Self | ★ 5.3 |
| 2020 | Feeding America Comedy Festival | Self | ★ 6.8 |
| 2020 | This Is Stand-Up | Self | ★ 5.0 |
| 2020 | LA Originals | Self | ★ 7.1 |
| 2019 | El Chicano | Captain Gomez | ★ 6.6 |
| 2018 | Tag der Vergeltung - Ein Vater sieht rot | Javier | ★ 5.3 |
| 2018 | Survivor's Guide to Prison | Self | ★ 6.4 |
| 2017 | George Lopez: The Wall | Himself | ★ 6.4 |
| 2017 | Gnomes & Trolls | Zook (voice) | ★ 6.1 |
| 2017 | Car Dogs | Christian | ★ 5.5 |
| 2017 | I Am Battle Comic | | ★ 9.0 |
| 2016 | Habla y vota | Himself | ★ 0.0 |
| 2016 | Meet the Blacks | President El Bama | ★ 4.8 |
| 2015 | Eddie Murphy: The Kennedy Center Mark Twain Prize | Self | ★ 8.0 |
| 2015 | The Latin Explosion: A New America | Self | ★ 7.9 |
| 2015 | Spare Parts | Fredi Cameron | ★ 7.2 |
| 2014 | Richard Pryor: Icon | Himself | ★ 6.2 |
| 2014 | The Concert for Valor | Self | ★ 8.6 |
| 2014 | School Dance | Oscar | ★ 7.4 |
| 2014 | Rio 2 - Dschungelfieber | Rafael (voice) | ★ 6.5 |
| 2013 | Zombies - An Undead Road Movie | Dr. Lyle | ★ 5.9 |
| 2013 | Die Schlümpfe 2 | Grouchy Smurf (voice) | ★ 5.7 |
| 2013 | Richard Pryor: Omit the Logic | Self | ★ 7.1 |
| 2012 | Nix wie weg - vom Planeten Erde | Thurman (voice) | ★ 5.7 |
| 2012 | Beverly Hills Chihuahua 3 - Viva La Fiesta! | Papi (voice) | ★ 6.3 |
| 2012 | George Lopez: It's Not Me, It's You | Self | ★ 5.4 |
| 2011 | Die Schlümpfe - Eine schlumpfige Weihnachtsgeschichte | Grouchy (voice) | ★ 6.7 |
| 2011 | Die Schlümpfe | Grouchy Smurf (voice) | ★ 5.8 |
| 2011 | Rio | Rafael (voice) | ★ 6.7 |
| 2011 | Beverly Hills Chihuahua 2 | Papi (voice) | ★ 5.9 |
| 2010 | Marmaduke | Carlos (voice) | ★ 5.2 |
| 2010 | Valentinstag | Alphonso Rodriguez | ★ 5.9 |
| 2010 | Back From Hell: A Tribute to Sam Kinison | Self | ★ 6.2 |
| 2010 | Spy Daddy | Glaze | ★ 5.9 |
| 2009 | Just for Laughs: Launching Pad | | ★ 0.0 |
| 2009 | George Lopez: Tall, Dark & Chicano | Himself | ★ 5.6 |
| 2009 | Mr. Troop Mom | Eddie Serrano | ★ 6.0 |
| 2009 | We Are One: The Obama Inaugural Celebration at the Lincoln Memorial | Self | ★ 4.6 |
| 2008 | Tortilla Heaven | Everardo | ★ 4.6 |
| 2008 | Beverly Hills Chihuahua | Papi (voice) | ★ 5.4 |
| 2008 | Viva la Causa | Narrator | ★ 0.0 |
| 2008 | Henry Poole - Vom Glück verfolgt | Father Salizar | ★ 5.9 |
| 2008 | Swing Vote - Die beste Wahl | John Sweeney | ★ 5.7 |
| 2008 | The Naked Brothers Band: Polar Bears | Self | ★ 0.0 |
| 2008 | Loco Comedy Jam Volume 1 | Self | ★ 0.0 |
| 2007 | Mr. Warmth: The Don Rickles Project | Self | ★ 6.8 |
| 2007 | Brown Is the New Green: George Lopez and the American Dream | Himself | ★ 0.0 |
| 2007 | Balls of Fury | Agent Ernie Rodriquez | ★ 5.2 |
| 2007 | George Lopez: America's Mexican | Himself | ★ 7.5 |
| 2005 | George Lopez: Why You Crying? | Himself | ★ 8.8 |
| 2005 | Die Abenteuer von Sharkboy und Lavagirl | Mr. Electricidad / Tobor / Ice Guardian | ★ 5.2 |
| 2004 | Naughty or Nice | Henry Ramiro | ★ 4.5 |
| 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self | ★ 8.0 |
| 2002 | Echte Frauen haben Kurven | Mr. Guzman | ★ 6.1 |
| 2002 | Outta Time | Felix | ★ 1.5 |
| 2002 | The Original Latin Kings of Comedy | Himself | ★ 5.7 |
| 2000 | Bread and Roses | Perez | ★ 6.3 |
| 1993 | Crazy Instinct | Murder Investigator | ★ 5.4 |
| 1990 | Ski Academy | Eddie Martinez | ★ 4.8 |
