| 2024 | Rettet Bikini Bottom: Der Sandy Cheeks Film | Sue Nahmee | ★ 5.8 |
| 2024 | Outstanding: A Comedy Revolution | Self | ★ 6.2 |
| 2024 | Underwater Projects | Narrator | ★ 0.0 |
| 2023 | Albert Brooks: Defending My Life | Self | ★ 7.3 |
| 2023 | Wanda Sykes: I'm an Entertainer | Self | ★ 6.6 |
| 2022 | Stand Out: An LGBTQ+ Celebration | | ★ 5.0 |
| 2021 | The One and Only Dick Gregory | Self | ★ 7.8 |
| 2021 | Roll Up Your Sleeves | Self | ★ 7.5 |
| 2021 | Breaking News in Yuba County | Rita | ★ 5.8 |
| 2020 | Dinner with Friends | Fairy Gay Mother #1 | ★ 4.7 |
| 2020 | Noah's Arc: The 'Rona Chronicles | | ★ 0.0 |
| 2020 | Feeding America Comedy Festival | Self | ★ 6.8 |
| 2019 | Jexi | Denice | ★ 6.8 |
| 2019 | The Wedding Year | Janet / Grandma | ★ 5.9 |
| 2019 | Live in Front of a Studio Audience: Norman Lear's "All in the Family" and "The Jeffersons" | Louise Jefferson | ★ 6.5 |
| 2019 | Wanda Sykes: Not Normal | Herself | ★ 7.0 |
| 2019 | UglyDolls | Wage (voice) | ★ 6.6 |
| 2018 | Julia Louis-Dreyfus: The Kennedy Center Mark Twain Prize | Self | ★ 0.0 |
| 2018 | Hurricane Bianca: From Russia with Hate | Prison Matron | ★ 5.2 |
| 2017 | Bad Moms 2 | Dr. Elizabeth Karl | ★ 6.3 |
| 2017 | Mädelstrip | Ruth | ★ 5.4 |
| 2016 | Wanda Sykes: What Happened… Ms. Sykes? | Herself | ★ 6.1 |
| 2016 | Do I Look Like a Lady? (Comedians and Singers) | Self (archive footage) | ★ 0.0 |
| 2016 | Bad Moms | Dr. Elizabeth Karl | ★ 6.5 |
| 2016 | Ice Age - Kollision voraus! | Granny (voice) | ★ 6.1 |
| 2015 | How to Vajaculate: If You Build It, She Will Come | Goddess | ★ 1.0 |
| 2013 | The Hot Flashes | Florine Clarkston | ★ 4.7 |
| 2013 | The Out List | Herself | ★ 6.1 |
| 2012 | Ice Age 4 - Voll verschoben | Granny (voice) | ★ 6.4 |
| 2011 | Rio | Chloe / Goose (voice) | ★ 6.7 |
| 2009 | Wanda Sykes: I'ma Be Me | Herself | ★ 7.6 |
| 2007 | Lizenz zum Heiraten | Doctor (uncredited) | ★ 5.7 |
| 2007 | Evan Allmächtig | Rita | ★ 5.6 |
| 2006 | Back to the Well: 'Clerks II' | Self / Wife | ★ 6.9 |
| 2006 | Hammys Bumerang Abenteuer | Stella (voice) | ★ 6.1 |
| 2006 | Wanda Sykes: Sick and Tired | Herself | ★ 7.9 |
| 2006 | Bärenbrüder 2 | Innoko (voice) | ★ 6.7 |
| 2006 | Der tierisch verrückte Bauernhof | Bessy the Cow (voice) | ★ 5.9 |
| 2006 | Clerks 2 - Die Abhänger | Wife | ★ 6.9 |
| 2006 | Die Super-Ex | Carla Dunkirk | ★ 5.1 |
| 2006 | Ab durch die Hecke | Stella (voice) | ★ 6.6 |
| 2006 | World's Greatest Stand Up: Volume One | self | ★ 0.0 |
| 2006 | Die Abenteuer von Bruder Hase | Sister Moon (voice) | ★ 6.1 |
| 2005 | Earth to America | Self | ★ 8.0 |
| 2005 | Just for Laughs Stand Up, Vol. 1: Best of the Uptown Comics | Herself | ★ 8.0 |
| 2005 | Das Schwiegermonster | Ruby | ★ 6.2 |
| 2003 | MTV Reloaded | The Oracle | ★ 7.3 |
| 2003 | Wanda Sykes: Tongue Untied | Herself | ★ 5.6 |
| 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self | ★ 8.0 |
| 2001 | Best of the Chris Rock Show: Volume 2 | | ★ 0.0 |
| 2001 | Pootie Tang | Biggie Shorty | ★ 5.0 |
| 2001 | Einmal Himmel und zurück | Wanda | ★ 5.5 |
| 2000 | Familie Klumps und der verrückte Professor | Chantal | ★ 5.0 |
| 1998 | Tomorrow Night | Wanda | ★ 5.9 |
| Undercard | Cheryl 'No Mercy' Stewart | ★ 0.0 |
| Tangles | | ★ 0.0 |
