| 2025 | Tonight's Special with Kareem & Johnny | Herself | ★ 8.0 |
| 2025 | This Is the Tom Green Documentary | Self (archive footage) | ★ 7.3 |
| 2024 | Boys Go to Jupiter | Dr. Dolphin (voice) | ★ 7.3 |
| 2022 | The Apology - Die Rache einer Mutter | Gretchen Sullivan | ★ 6.1 |
| 2022 | The Kids in the Hall: Comedy Punks | Self | ★ 7.0 |
| 2021 | Too Soon: Comedy After 9/11 | Self | ★ 5.0 |
| 2021 | The God Committee | Dr. Valerie Gilroy | ★ 6.6 |
| 2021 | Flora & Ulysses | Marissa | ★ 6.5 |
| 2020 | Asking for It | Cheryl | ★ 5.6 |
| 2020 | Come as you are - Roadtrip ins Leben | Liz | ★ 6.5 |
| 2019 | 25 Sets | Self | ★ 0.0 |
| 2019 | Other Music | Self | ★ 6.8 |
| 2019 | Mercy Black | Dr. Ward | ★ 6.0 |
| 2019 | It Started As a Joke | Self | ★ 4.8 |
| 2018 | Be Natural — Sei du selbst: Die Filmpionierin Alice Guy-Blaché | Self | ★ 7.3 |
| 2018 | A Bread Factory: Part One: For the Sake of Gold | Jordan | ★ 6.6 |
| 2018 | Hurricane Bianca: From Russia with Hate | Magda | ★ 5.2 |
| 2018 | The Happys | Luann | ★ 5.7 |
| 2018 | Submission | Magda Moynahan | ★ 5.9 |
| 2018 | Lovesick Fool - Love in the Age of Like | Natalie | ★ 0.0 |
| 2017 | Little Boxes | Helena | ★ 6.2 |
| 2017 | Sandy Wexler | Testimonial | ★ 5.5 |
| 2017 | Speech & Debate | Marie | ★ 6.0 |
| 2017 | Michael Bolton's Big, Sexy Valentine's Day Special | Janeane Garofalo | ★ 6.3 |
| 2017 | Werewolf Bitches from Outer Space | Art Gallery Owner | ★ 1.5 |
| 2016 | Janeane Garofalo: If I May | Self | ★ 5.5 |
| 2016 | The American Side | Agent Barry | ★ 4.7 |
| 2016 | Sticky: A (Self) Love Story | Self | ★ 5.3 |
| 2015 | Thank You, Del: The Story of the Del Close Marathon | Self | ★ 5.6 |
| 2015 | Hurricane of Fun: The Making of Wet Hot | Self | ★ 6.4 |
| 2015 | 3rd Street Blackout | June Sherman | ★ 9.0 |
| 2015 | Adventures in Comedy | | ★ 3.0 |
| 2015 | Misery Loves Comedy | Self | ★ 6.0 |
| 2014 | Free the Nipple | Anouk | ★ 4.7 |
| 2014 | A Little Game | Sarah Kuftinec | ★ 6.5 |
| 2014 | Showing Up | Self | ★ 9.2 |
| 2013 | The Muslims Are Coming! | Self | ★ 10.0 |
| 2013 | Satan, Hold My Hand | Sheryl | ★ 0.0 |
| 2013 | Never Before, Never Again: Behind the Scenes of Asssscat | Self | ★ 3.5 |
| 2013 | Why We Laugh: Funny Women | Self | ★ 7.2 |
| 2012 | Bad Parents | Kathy | ★ 3.7 |
| 2012 | General Education | Gale Collins | ★ 4.6 |
| 2012 | Vanilla Ice Archive | Self (archive footage) | ★ 0.0 |
| 2012 | Mighty Fine | Narrator (voice) | ★ 4.4 |
| 2010 | Janeane Garofalo: If You Will | Self | ★ 5.8 |
| 2010 | I Am Comic | Self | ★ 6.3 |
| 2009 | Love Hurts | Hannah Rosenbloom | ★ 5.1 |
| 2009 | Wie das Leben so spielt | Friend in video (archive footage) (uncredited) | ★ 5.9 |
| 2009 | (K)Ein bisschen schwanger | Claire | ★ 5.4 |
| 2008 | The Guitar | Dr. Murray | ★ 5.6 |
| 2008 | Tropic Thunder: Rain of Madness | Heidi Bivens | ★ 6.8 |
| 2008 | Girl's Best Friend | Mary | ★ 4.5 |
| 2008 | A Bad Situationist | Lenore Stein | ★ 0.0 |
| 2007 | Southland Tales | General Teena MacArthur | ★ 5.2 |
| 2007 | Als sie mich fand | Janeane Garofalo | ★ 5.6 |
| 2007 | Das 10 Gebote Movie | Nuclear Powerplant Shift Supervisor Beth Soden | ★ 4.8 |
| 2007 | Ratatouille | Colette (voice) | ★ 7.8 |
| 2007 | Law Dogs | Gloria Fontaine | ★ 0.0 |
| 2007 | The Making Of 'The Larry Sanders Show' | Paula | ★ 0.0 |
| 2006 | Fuck | Self | ★ 6.4 |
| 2006 | Tierisch Wild | Bridget (voice) | ★ 5.5 |
| 2006 | Al Franken: God Spoke | Self | ★ 6.9 |
| 2005 | Duane Hopwood | Linda | ★ 5.7 |
| 2005 | Stay | Dr. Beth Levy | ★ 6.6 |
| 2005 | Nadine in Dateland | Nadine | ★ 5.0 |
| 2005 | Jiminy Glick in Gagawood | Dee Dee | ★ 4.4 |
| 2005 | Left of the Dial | Self | ★ 7.5 |
| 2004 | Nobody Knows Anything! | Patty | ★ 3.1 |
| 2003 | Saturday Night Live: The Best of Chris Farley | Quiz Kings Contestant (archive footage) (uncredited) | ★ 7.6 |
| 2003 | Wonderland | Joy Miller | ★ 6.1 |
| 2003 | Outlaw Comic: The Censoring of Bill Hicks | Self - Host | ★ 6.3 |
| 2003 | Dangerous Living: Coming Out in the Developing World | Narrator (voice) | ★ 4.7 |
| 2003 | Gigantic (A Tale of Two Johns) | Self | ★ 8.2 |
| 2003 | The Very Best of America's Funniest Comedians | Self (archive footage) | ★ 0.0 |
| 2003 | Ash Tuesday | Liz | ★ 5.8 |
| 2003 | Manhood | Jill | ★ 4.5 |
| 2003 | When Stand Up Stood Out | Self | ★ 6.0 |
| 2002 | Martin & Orloff | Hairdresser | ★ 5.4 |
| 2002 | Jede Menge Ärger | Monica Romero | ★ 6.1 |
| 2002 | Das Laramie-Projekt | Catherine Connolly | ★ 6.5 |
| 2001 | The Search for John Gissing | Linda Barnes | ★ 4.5 |
| 2001 | Wet Hot American Summer | Beth | ★ 6.3 |
| 2001 | Laughing Out Loud: America's Funniest Comedians | Self (archive footage) | ★ 6.0 |
| 2001 | Housekeeping | Hotel Employee ( voice) | ★ 0.0 |
| 2000 | King of B-Movies | Paloma Fineman | ★ 5.7 |
| 2000 | Steal This Movie | Anita Hoffman | ★ 5.8 |
| 2000 | Die Abenteuer von Rocky und Bullwinkle | Minnie Mogul | ★ 4.2 |
| 2000 | Titan A.E. | Stith (voice) | ★ 6.6 |
| 2000 | Good Vibrations - Sex vom anderen Stern | Nervous Woman | ★ 5.5 |
| 2000 | Behind the Scenes at Daria | Host | ★ 8.7 |
| 2000 | Freunde bis zum Tod | Dr. Harriman | ★ 6.4 |
| 2000 | Daring to Resist: Three Women Face the Holocaust | Narrator | ★ 0.0 |
| 1999 | Dogma | Liz | ★ 6.9 |
| 1999 | The N.Y. Friars Club Roast of Jerry Stiller | Self | ★ 5.3 |
| 1999 | Let Me In, I Hear Laughter: A Salute to the Friars Club | Self | ★ 0.0 |
| 1999 | Mystery Men | Bowler / Carol | ★ 5.8 |
| 1999 | The Last Bandit | Anne | ★ 5.9 |
| 1999 | Eine Nacht in New York | Ellie | ★ 5.9 |
| 1999 | The Minus Man | Ferrin | ★ 5.4 |
| 1999 | Can't Stop Dancing | Belinda Peck | ★ 2.0 |
| 1999 | Torrance Rises | Self | ★ 7.8 |
| 1998 | The Thin Pink Line | Joyce Wintergarden-Dingle | ★ 5.7 |
| 1998 | Clay Pigeons - Lebende Ziele | Agent Dale Shelby | ★ 6.2 |
| 1998 | Permanent Midnight - Voll auf Droge | Jana Farmer | ★ 6.0 |
| 1998 | Dog Park - Bei Fuß, Liebling! | Jeri | ★ 5.5 |
| 1998 | Half Baked - Völlig high und durchgeknallt | I'm Only Creative When I Smoke Smoker (uncredited) | ★ 6.3 |
| 1998 | Saturday Night Live: A Tribute to Chris Farley | Self | ★ 4.5 |
| 1997 | Sweethearts | Jasmine Pogue | ★ 2.7 |
| 1997 | Heirat nicht ausgeschlossen | Marcy Tizard | ★ 6.2 |
| 1997 | Janeane Garofalo: HBO Comedy Hour | Self | ★ 0.0 |
| 1997 | Cop Land | Deputy Cindy Betts | ★ 6.8 |
| 1997 | Romy und Michele | Heather Mooney | ★ 6.2 |
| 1997 | Touch | Kathy Worthington | ★ 5.8 |
| 1996 | I Shot a Man in Vegas | Gale | ★ 3.0 |
| 1996 | Die dicke Vera | Mo | ★ 5.5 |
| 1996 | Cable Guy - Die Nervensäge | Medieval Times Waitress | ★ 6.0 |
| 1996 | Lügen haben lange Beine | Abby | ★ 6.0 |
| 1996 | Brain Candy | Woman at Party | ★ 6.2 |
| 1995 | The State's 43rd Annual All-Star Halloween Special | Self | ★ 4.0 |
| 1995 | Now and Then - Damals und heute | Wiladene | ★ 6.9 |
| 1995 | Cold Blooded | Honey | ★ 6.4 |
| 1995 | HBO Comedy Half-Hour: Janeane Garofalo | Self | ★ 6.0 |
| 1995 | Bye Bye Love | Lucille | ★ 5.9 |
| 1994 | Voll das Leben - Reality Bites | Vickie Miner | ★ 6.6 |
| 1994 | Suspicious | Woman | ★ 5.0 |
| 1991 | Late for Dinner - Eine zeitlose Liebe | Counter Girl | ★ 5.6 |
| Best of the Improv Vol. 1 | Self (archive footage) | ★ 0.0 |
| The Peace Patriots | Narrator (voice) | ★ 0.0 |
