| 2025 | She Raised Me | Marilyn Muff | ★ 0.0 |
| 2025 | Liza: A Truly Terrific Absolutely True Story | Self (archive footage) (uncredited) | ★ 7.6 |
| 2024 | Outstanding: A Comedy Revolution | Self | ★ 6.2 |
| 2023 | Der Fall Matthew Shepard | Self | ★ 4.7 |
| 2023 | Rosie's Theater Kids | Herself | ★ 0.0 |
| 2023 | Being Mary Tyler Moore | Self (voice) | ★ 6.8 |
| 2023 | Meat Loaf - A Celebration Of Life | Self | ★ 0.0 |
| 2022 | Hollywoods Casting-Queen: Bonnie | Self | ★ 5.0 |
| 2022 | Stand Out: An LGBTQ+ Celebration | | ★ 5.1 |
| 2020 | Love, Loss, and What I Wore | | ★ 0.0 |
| 2020 | Together in Pride: You Are Not Alone | Self | ★ 10.0 |
| 2017 | Broadway: The Next Generation | Self | ★ 10.0 |
| 2017 | The Words That Built America | Self - Reader: Declaration of Independence | ★ 6.0 |
| 2016 | Hairspray Live! | Gym Teacher | ★ 7.4 |
| 2015 | Everything Is Copy | Self | ★ 7.4 |
| 2015 | Pitch Perfect 2 | The View Host | ★ 6.8 |
| 2015 | Rosie O'Donnell: A Heartfelt Stand Up | Self | ★ 7.8 |
| 2014 | The (Dead Mothers) Club | Self | ★ 6.3 |
| 2012 | Me @ the Zoo | Self (archive footage) | ★ 4.2 |
| 2011 | Being Elmo: A Puppeteer's Journey | Self | ★ 7.2 |
| 2011 | The Undefeated | Self (voice) | ★ 2.0 |
| 2011 | 9/11 Truth: Hollywood Speaks Up | Self | ★ 5.8 |
| 2010 | One Night Only - Barbra Streisand and Quartet at the Village Vanguard | Áudience | ★ 7.1 |
| 2010 | A Family Is a Family Is a Family: A Rosie O'Donnell Celebration | Herself | ★ 3.8 |
| 2010 | Teenage Paparazzo | Self | ★ 7.0 |
| 2009 | America | Dr. Maureen Brennan | ★ 3.5 |
| 2007 | ShowBusiness: The Road to Broadway | Self | ★ 7.2 |
| 2006 | The Madness of Boy George | Self (archive footage) | ★ 3.5 |
| 2006 | All Aboard! Rosie's Family Cruise | Herself | ★ 4.0 |
| 2005 | I'm Going to Tell You a Secret | Self | ★ 6.7 |
| 2005 | Riding the Bus with My Sister | Beth Simon | ★ 3.4 |
| 2005 | The Lady in Question Is Charles Busch | Self | ★ 5.7 |
| 2005 | Pursuit of Equality | Self | ★ 1.0 |
| 2003 | The Very Best of America's Funniest Comedians | Self (archive footage) | ★ 0.0 |
| 2003 | Listen to Her Heart: The Life and Music of Laurie Beechman | Narrator | ★ 0.0 |
| 2003 | The Golden Girls: Lifetime Intimate Portrait Series | Self | ★ 9.4 |
| 2002 | Artists and Orphans: A True Drama | Narrator | ★ 0.0 |
| 2001 | Last Party 2000 | Self | ★ 6.1 |
| 2001 | Hedwig and the Angry Inch | Self (uncredited) | ★ 7.4 |
| 2001 | The Gun Deadlock | Self | ★ 0.0 |
| 2001 | Laughing Out Loud: America's Funniest Comedians | Self (archive footage) | ★ 6.0 |
| 2000 | Die Flintstones in Viva Rock Vegas | Octopus Masseuse (voice) | ★ 4.8 |
| 1999 | A Rosie Christmas | Host | ★ 0.0 |
| 1999 | Tarzan | Terk (voice) | ★ 7.4 |
| 1999 | Jackie's Back! | Rosie O'Donnell | ★ 6.5 |
| 1998 | Kids Are Punny | Baby Rosie (voice) | ★ 5.0 |
| 1998 | Celine: These Are Special Times | Self | ★ 8.0 |
| 1998 | Wide Awake | Sister Terry | ★ 5.5 |
| 1998 | Sesame Street: Elmopalooza! | Self | ★ 5.8 |
| 1997 | Say It, Fight It, Cure It | Self | ★ 0.0 |
| 1997 | Austin Powers' Electric Psychedelic Pussycat Swingers Club | The Swingers Club | ★ 5.5 |
| 1997 | Walt Disney World's 25th Anniversary Party | Self | ★ 5.5 |
| 1997 | Happy Birthday Elizabeth: A Celebration of Life | Self | ★ 7.3 |
| 1996 | Zeit der Zweifel | Jackie | ★ 5.6 |
| 1996 | Die Brady Family 2 | Rosie O'Donnell (uncredited) | ★ 5.8 |
| 1996 | Harriet, die kleine Detektivin | Ole Golly | ★ 6.1 |
| 1996 | The Good, The Bad, and the Beautiful | Self | ★ 10.0 |
| 1996 | Beautiful Girls | Gina Barrisano | ★ 6.7 |
| 1995 | Now and Then - Damals und heute | Roberta | ★ 6.9 |
| 1995 | Rosie O'Donnell | Self | ★ 4.0 |
| 1994 | Undercover Cops | Sheila Kingston | ★ 4.1 |
| 1994 | Flintstones: Die Familie Feuerstein | Betty Rubble | ★ 5.3 |
| 1994 | Sesame Street | All-Star 25th Birthday: Stars and Street Forever! | Good Hope Fairy | ★ 7.0 |
| 1994 | Geht’s hier nach Hollywood? | Makeup | ★ 5.5 |
| 1994 | Wagen 54 - Bitte Melden | Lucille Toody | ★ 3.3 |
| 1993 | Crazy Instinct | Woman in Bird Store | ★ 5.4 |
| 1993 | Die Abservierer | A.D.A. Gina Garrett | ★ 5.5 |
| 1993 | Schlaflos in Seattle | Becky | ★ 6.7 |
| 1992 | Eine Klasse für sich | Doris Murphy (3B) | ★ 7.2 |
| The Grievance | Louise | ★ 0.0 |
