Florence Reed

Lucretia Borgia

William E. Shay

The Duke of Ferrara

Stephen Grattan

Lucretia's Brother

Richard Barthelmess

Gennaro

Alex Shannon

Rustighello

A.G. Parker

Maffio

M.J. Briggs

Astolpo

Edward Thorne

Jeppo

Elmer Patterson

Liverretto

Tony Merlo

Petrucci

Henry Armetta

The Jester

William Welsh

Gubetta

Juliet Brenon

Blanca

Jane Fearnley

Princess Negroni

Henrietta Gilbert

Flametta

Charles Ray Howard